People with sickle cell disease have a harder time fighting viruses and bacteria because their spleen (which acts as a filter for bacteria) does not work normally. This risk is highest in young children, followed by adolescents and adults.
Infections are the most common cause of death in people with sickle cell disease. The risk of infection is high because the spleen (which acts as a filter for bacteria) does not work normally in people with sickle cell disease. This risk is highest in young children. Adolescents and adults are also at a higher risk compared to people without sickle cell disease (see the Fever and Infections section for more information).