Adults with sickle cell disease are more likely to get leg ulcers than adults without sickle cell disease.
When red blood cells sickle and block blood flow to an area of injured skin, it takes longer to heal. These injuries can turn into an ulcer or an open sore.
Ulcers may also happen without a known injury. The most common places for ulcers are on the outside of the ankles. They tend to last for long periods of time and can be painful.