The gallbladder is a small sac located on the right side of the belly. Its job is to store bile. It releases bile into the intestines after eating. This helps with digestion, especially after eating fatty food.
It is common for people who have sickle cell disease to develop stones in their gallbladder. These gallstones form when there is too much bilirubin in the blood.
Bilirubin is released into the blood when red blood cells break down. Because the red blood cells of people with sickle cell disease break down faster, more bilirubin is released, so the risk of gallstones is higher.
Most gallstones do not cause problems. But if a gallstone moves and gets stuck between the gallbladder and the intestines, it may cause a blockage.